Director, Behavioral Cardiovascular Health and Hypertension Program

Columbia Presbyterian Medical Center

PH 9-946
622 West 168 th Street
New York 10032

Telephone: 212-342-4489

Fax: : 212-305-3172

E-mail: tp2114@columbia.edu

Academic Training

BA, MA Trinity College , Cambridge University 1962

MB, B Chir Middlesex Hospital Medical School , London : 1966

M.R.C.P. Royal College of Physicians , London 1968

D Phil Linacre College , Oxford University : 1970

F.R.C.P. Royal College of Physicians , London 1980

Affiliations

2003- Director, Behavioral Cardiovascular Health & Hypertension Program,

Columbia University , College of Physicians & Surgeons

2001- Cardiorenal Advisory Board, Food and Drug Administration

Summary of Research Interests

•  New methods of blood pressure measurement, particularly the use of 24 hour ambulatory monitoring and self monitoring, and the significance of white coat and masked hypertension.

•  The role of stress in hypertension and heart disease

•  Sleep and hypertension

•  Methods of improving adherence and control of hypertension

Selected Publications

Gerin, W., Pieper, C., Levy, R., and Pickering , T.G. Social support in social interaction: A moderator of cardio­vascular reactivity. Psychosomatic Medicine, 1992;54:324-336.

Pickering , T.G. The ninth Sir George Pickering memorial lecture. Ambulatory monitoring and the definition of hypertension. Journal of Hypertension, 1992;0:401-409.

Pickering , T.G. and James, G.D. Determinants and consequences of the diurnal rhythm of blood pressure. American Journal of Hypertension , 1993;6:266s-269s.

Pickering , T.G. Blood platelets, stress and cardiovascular disease. Psychosomatic Medicine, 1993;55(6):483.

Pickering , T.G. Hypertension in blacks. Current Opinion in Nephrology & Hypertension, 1994;Vol. 3, No. 2, pp. 207-212.

Pickering , T.G. Hypertension octet: Blood pressure measurement and detection of hypertension. The Lancet, 1994;Vol. 344, No. 8914, pp. 31-35.

Schwartz, J.E., Warren , K., and Pickering , T.G. Mood, location and physical position as predictors of ambulatory blood pressure and heart rate: application of a multi-level random effects model. Annals of Behavioral Medicine, 1994;Vol. 16, No. 3, pp. 210-220.

Cavallini MC, Roman MJ, Pickering T.G., Schwartz JE, Pini R, Devereux RB. Is white coat hypertension associated with arterial disease or left ventricular hypertrophy? Hypertens , 1995; 26:413-419.

Pickering T.G. , Kaplan NM, Krakoff L, Prisant LM, Sheps S, Weber MA, White WB. American Society of Hypertension Expert Panel: Conclusions and recommendations on the clinical use of home (self) and ambulatory blood pressure monitoring. Am J Hypertens, 1996;9:1-11.

Gerin W, Pickering T.G. , Pieper C. Breaking the barriers to compliance with medication regimens. Cardiology Review, 1996;13: 14-20.

Stone AA, Smyth JM, Pickering T.G. , Schwartz JE. Daily mood variability: form of diurnal patterns and determinants of diurnal patterns. J Appl Soc Psychol, 1996;26:1286-1305.

Yamasaki F, Schwartz JE, Gerber LM, Warren K, Pickering T.G. Impact of shift work and race/ethnicity on the diurnal rhythm of blood pressure and catecholamines. Hypertension, 1998;32:417-423.

Schnall PL, Schwartz JE, Landsbergis PA, Warren K, Pickering T.G. A longitudinal study of job strain and ambulatory blood pressure: results from a three-year follow-up. Psychosom Med, 1999;60:697-706.

Pickering T.G. Depression, race, hypertension, and the heart. J Clin Hypertens , 2000; 11:410-412.

Kario K, Pickering T.G. Does extreme dipping of nocturnal blood pressure in elderly hypertensive patients confer high risk of developing ischemic target organ damage from antihypertensive therapy? Arch Intern Med, 2000;160:1378

Kario K, Pickering T.G. Blood pressure variability in elderly patients. Lancet, 2000;355:1645-6.

Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, D'Agostino RB, Newman AB, Lebowitz MD, Pickering T.G. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. Jama , 2000;283:1829-36.

Devereux RB, Case DB, Alderman MH, Pickering T.G. , Chien S, Laragh JH. Possible role of increased blood viscosity in the hemodynamics of systemic hypertension. Am J Cardiol, 2000;85:1265-8.

Roman MJ, Ganau A, Saba PS, Pini R, Pickering T.G. , Devereux RB. Impact of arterial stiffening on left ventricular structure. Hypertension, 2000;36:489-94.

Kario K, Schwartz JE, Davidson KW, Pickering T.G. Gender differences in associations of diurnal blood pressure variation, awake physical activity, and sleep quality with negative affect: the work site blood pressure study. Hypertension, 2001;38:997-1002.

Kario K, Shimada K, Schwartz JE, Matsuo T, Hoshide S, Pickering T.G. Silent and clinically overt stroke in older Japanese subjects with white-coat and sustained hypertension. J Am Coll Cardiol, 2001;38:238-45.

Roman MJ, Pickering T.G. , Schwartz JE, Pini R, Devereux RB. Relation of blood pressure variability to carotid atherosclerosis and carotid artery and left ventricular hypertrophy. Arterioscler Thromb Vasc Biol , 2001;21:1507-11.

Kario K, Pickering T.G. , Umeda Y, Hoshide S, Hoshide Y, Morinari M, Murata M, Kuroda T, Schwartz JE, Shimada K. Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study. Circulation, 2003;107:1401-1406.

Currently Funded Projects

ACTIVE

P01 HL 47540 (T. Pickering, P.I.) 9/01/2003-8/31/2008 47%
NIH/NHLBI $1,643,537
This proposal contains three projects which all bear on aspects of the development of Hypertension. Project 1 is titled: International Follow-Up of ABPM and Cardiac Events , and the major goals of this study are to compile an international database of retrospective ambulatory blood pressure monitorings and prospectively follow up cardiac events. Project 2 is titled: Masked Hypertension – Risk Factors and Consequences and will examine the effects of masked hypertension on measures of target organ damage in a working population. Project 3 is titled: Effects of Angry Perseverative Cognition on ABP and will establish the cognitive and affective underpinnings of sustained blood pressure elevation following an anger recall task, and the generalizability of these elevations to the natural environment.

R01 HL67439 (W. Gerin, P.I.) 09/17/01-08/31/06 7%
NIH/NHLBI $496,183
A STEPPED INTERVENTION FOR MEDS ADHERENCE AND BLOOD PRESSURE CONTROL
The major goals of this project are to test the effects of two commercially available interventions on medication adherence in hypertensive patients, and on blood pressure control, using an RCT pre-post design.

HC 25197 (K. Davidson, P.I.) 09/30/02-09/29/2007 26%
NIH/NHLBI $2,132,285
CONSORTIUM FOR THE TRANSLATION OF PSYCHOSOCIAL DEPRESSION THEORIES TO INTERVENTION AND DISSEMINATION
The major goals of this contract are to understand the etiology, course, and treatment of the dysphoria following an acute coronary syndrome.

R01 HL73495 (T. Pickering, P.I.) 09/1/02-08/31/2007 20%
NIH/NHLBI $402,324
CONDITIONED PLACEBO EFFECTS AND T REATMENT OF HT
The major goal of this project is to test the hypothesis that placebo pills given to lower blood pressure will have a greater effect if given after the active medication than before it.

K23 HL04458 (KW Davidson, PI ) 9/4/2000-8/31/2006 Mentor
NIH/NHLBI $118,525
CONTROLLED RANDOMIZED ANGER REDUCTION IN HYPERTENSIVES
The major goals of this project are to test a randomized controlled behavioral intervention to determine if it reduces blood pressure in previously uncontrolled hypertensives.

K23 HL072866-01 (D. Shimbo, P.I.) 7/1/03 - 6/30/08 Mentor
TRANSLATIONAL STUDY OF HOSTILITY, ATHEROTHROMBOSIS & CAD
The major goal of this career development award is to enable Dr. Daichi Shimbo to develop into an independent, translational researcher with expertise in preventive cardiology. The goals of the proposed research program are to examine the relationship between hostility and its management on levels of inflammatory markers and platelet reactivity.

PENDING

RFA OB-03-004 (T. Pickering, P.I.) 05/1/04-04/31/2009 5%
NIH/NHLBI $ 635,073
MIND-BODY-BEHAVIORAL MED CLINICAL TRIALS INFRASTRUCTURE
This application proposes the development of infrastructure that will allow interdisciplinary study of the effects of stress and psychological dimensions on hypertension and heart disease. We propose to develop a website that will provide cutting-edge information, free of charge, on mechanisms (in cooperation with the MacArthur Foundation website, which covers some aspects of this), and will provide a Cochran review database describing behavioral medicine interventions.

K23 (C.Rodriguez, P.I.) 9/1/04 - 8/31/09 Mentor
NIH/NHLBI $149,859
ETHNICITY, STRESS, AND LEFT VENTRICULAR MASS
The major goal of this career development award is to enable Dr. Carlos J Rodriguez to develop into an independent researcher with expertise in cardiovascular epidemiology. The proposed research program will examine the interrelationship between psychosocial stress, race-ethnicity, and ambulatory blood pressure / left ventricular mass measures.