Education
1991 B.S., Biomedical Engineering, The Johns Hopkins University
1995 M.D., The Albany Medical College Training
1995-1996 Internship in Internal Medicine
The Mount Sinai School of Medicine
Mount Sinai Hospital
New York, NY
1996-1998 Residency in Internal Medicine
The Mount Sinai School of Medicine
Mount Sinai Hospital
New York, NY
1998-1999 Chief Residency in Internal Medicine
The Mount Sinai School of Medicine
Mount Sinai Hospital
New York, NY
1999-2001 Cardiology Research Fellow
Cardiovascular Biology Research Laboratory
The Zena & Michael A. Wiener Cardiovascular Institute
The Mount Sinai School of Medicine
Mount Sinai Hospital
New York, NY
2001-June 2003 Clinical Cardiology Fellow
The Zena & Michael A. Wiener Cardiovascular Institute
The Mount Sinai School of Medicine
Mount Sinai Hospital
New York, NY
Appointments and Titles
2003-Present Department of Medicine, Columbia University Medical Center, New York, NY
Victoria and Ester Aboodi Assistant Professor of Medicine
Division of Cardiology
Columbia University Medical Center
New York, NY
Florence Irving Assistant Professor of Medicine
Division of General Medicine
Columbia University Medical Center
New York, NY
Director of the Laboratory
Center for Behavioral Cardiovascular Health
Columbia University Medical Center
New York, NY
Director of Cardiovascular Physiology Research
Cardiovascular Ultrasound Laboratories
Columbia University Medical Center
New York, NY
Director of Information Technology
Cardiovascular Ultrasound Laboratories
Columbia University Medical Center
New York, NY
Summary of Research Interests
• Identifying novel cardiovascular risk factors.
• Exploring the molecular processes underlying the link between novel cardiovascular risk factors and heart disease.
• Exploring the mechanistic underpinnings of the link between psychosocial factors and cardiovascular disease.
• Cardiovascular imaging and testing.
Selected Publications
1.
Shimbo D, Geer E,
Child J, Osende JI, Reddy S, Badimon JJ, Fuster V. The antidepressant
nefazodone inhibits shear-induced platelet aggregation. J Am Coll Cardiol
2000; 35 Suppl A: 282
2.
Shimbo D, Geer E,
Child J, Dronge A, Farkouh M, Reddy S, Halperin J. The selective serotonin
reuptake inhibitor paroxetine inhibits endothelial-dependent vasodilatation. J
Am Coll Cardiol 2000; 35 Suppl A: 271
3.
Reddy S, Mosovich SA,
Shimbo D. Coronary artery disease and depression. Primary Psychiatry 2000;
7(9): 69-75
4.
Shimbo D, Osende J,
Reddy S. Excess risk of myocardial infarction in patients treated with
antidepressant medications. Am J Med 2000; 109: 68-69
5.
Osende JI, Fuster V,
Lev EI, Shimbo D, Rauch U, Marmur JD, Richard M, Varon D, Badimon JJ. Testing
platelet activation with a shear-dependent platelet function test versus
aggregation-based tests: relevance for monitoring long-term glycoprotein
IIb/IIIa inhibition. Circulation 2001; 103(11): 1488-1491
6.
Shimbo D, Osende JI,
Chen J, Mukherjee JT, Fuster V, Badimon JJ. Antithrombotic effects of DX-9065a,
a direct factor Xa inhibitor: a comparative study in humans versus low
molecular weight heparin. Thromb Haemost 2002 Nov;88(5):733-8
7.
Shimbo D, Child J,
Davidson K, Geer E, Osende JI, Reddy S, Dronge A, Fuster V, Badimon JJ.
Exaggerated serotonin-mediated platelet reactivity as a possible link in depression
and the acute coronary syndromes. Am J Cardiol 2002; 89(3): 331-333
8.
Farkouh ME, Robbins
MJ, Zafar MU, Shimbo D, Davidson KW, Puttappa R, Winston J, Halperin JL,
Epstein EM, Patel M, Talor Z, Chesebro JH. Troponin I predicts mortality in
stable chronic hemodialysis patients. Am J Med 2003 Feb 15;114(3):224-6
9.
Shimbo D, Pickering
T. Platelets in Cardiovascular and Non-cardiovascular Disorders:
Pathophysiology, Pharmacology and Therapeutics. Cardiovascular Reviews &
Reports 2004;25(1):18-24
10. Osende JI, Shimbo D, Fuster V, Dubar M,
Badimon JJ. Antithrombotic effects of S-18886, a novel orally active
thromboxane A2 receptor antagonist. J Thromb Haemost 2004 Mar;2(3):492-8
11. Pickering T, Davidson K, Shimbo D.
Anxiety, depression, and prognosis after myocardial infarction: is there a
causal association? J Am Coll Cardiol. 2004 Jul 21;44(2):472-3
12. Shimbo D, Davidson K, Haas D, Fuster V,
Badimon JJ. Negative Impact of Depression on Outcomes in Patients with
Coronary Artery Disease: Mechanisms, Treatment Considerations, and Future
Directions. J Thromb Haemost. 2005 May;3(5):897-908
13. Haas DC, Gerber LM, Shimbo D, Warren K,
Pickering TG, Schwartz JE. A
Comparison of Morning Blood Pressure Surge in African-Americans and Whites. Journal
of Clinical Hypertension 2005;7:205-209.
14. Shimbo D, Chaplin W, Crossman D, Haas D,
Davidson KW. Role of Depression and Inflammation in Incident Coronary Heart
Disease Events. American Journal of Cardiology. 2005 Oct
1;96(7):1016-21.
15. Gerin W, Ogedegbe G, Schwartz JE, Chaplin
WF, Goyal T, Clemow L, Davidson DW, Burg M, Lipsky S, Kentor R, Jhalani J,
Shimbo D, Pickering, TG. Assessment of the white coat effect. J Hypertens.
2006 Jan;24(1):67-74.
16. Haas DC, Chaplin WF, Shimbo D, Pickering
TG, Burg M, Davidson KW. Hostility is an Independent Predictor of Recurrent
Coronary Heart Disease Events in Men but not Women: Results from a
Population-based Study. Heart 2005;91:1609-10.
17. Raina A, Pickering T, Shimbo D. Statin
Use in Heart Failure: A Cause for Concern? Am Heart J. 2006
Jul;152:39-49
18. Shimbo D, Rieckmann N, Paulino R,
Davidson KW. The Relation Between C-reactive Protein and Depression Remission
Status in Patients Presenting with an Acute Coronary Syndrome. Heart. 2006
Sep;92:1316-8
19. Davidson KW, Haas DC, Shimbo D, Pickering
TG, & Jonas BS Standardizing the comparison of systolic blood Pressure vs
pulse pressure for predicting coronary heart disease. J Clin Hypertens.2006
Jun;8:411-3
20. LaRocca GM, Shimbo D, Rodriguez CJ,
Stewart A, Naka Y, Weinberger J, Homma S, Pizzarello R. The Impella Recover LP
5.0 Left Ventricular Assist Device: A Bridget to CABG and Cardiac Transplant. J
Am Soc Echocardiogr. 2006 Apr;19(4):468.e5-7
21. Pickering TG, Shimbo D, Haas DC.
Ambulatory Blood Pressure Monitoring. N Engl J Med. 2006 Jun
1;354(22):2368-74.
22. Kronish IM, Rieckmann N, Halm EA, Shimbo
D, Vorchheimer D, Haas DC, Davidson KW. Persistent
Depression Affects Adherence to Secondary Prevention Behaviors After Acute
Coronary Syndromes. J Gen Intern Med. 2006 Nov;21(11):1178-83.
23. Gerin W, Schwartz JE, Devereux RB, Goyal
T, Shimbo D, Ogedegbe G, Rieckmann N, Abraham D, Chaplin W, Burg M, Jhulani J,
Pickering TG. Superiority of ambulatory to physician blood pressure is not an
artifact of differential measurement reliability. Blood Press Monit.
2006;11(6):297-301.
24. Shimbo D, Grahame-Clarke C, Miyake Y,
Rodriguez C, Sciacca R, Di Tullio M, Boden-Albala B, Sacco R, Homma S. The Association
Between Endothelial Dysfunction and Cardiovascular Outcomes in a Multi-Ethnic
General Population - The Northern Manhattan Study. Atherosclerosis.
2007;192:197-203
25. Shimbo D, Homma S, Akinola O, Harris A,
Abraham D, Chaplin W, Gerin W. Anger Provocation Induces Impaired
Endothelium-Dependent and -Independent Vasodilation in Humans. American
Journal of Cardiology. 2007 May;20(5):476-82
26. Shimbo D, Pickering TG, Abraham D,
Schwartz JE, Gerin W. The Relative Utility of Home, Ambulatory, and Physician-Obtained
Blood Pressures in the Prediction of End-Organ Damage. Am J Hypertens. 2007
May;20(5):476-82
27. Zafar UM, Farkouh ME, Osende J, Shimbo D,
Palencia S, Crook J, Leadley R, Fuster V, Chesebro JH. Potent arterial
antithrombotic effect of direct factor-Xa inhibition with ZK-807834
administered to coronary artery disease patients. Thromb Haemost 2007;97:487-92
28. Goodman G, Shimbo D, Haas DC, Davidson
KW, Rieckmann N. Incident and recurrent major depressive disorder and coronary
artery disease severity in acute coronary syndrome patients. J Psychiatr Res.
2007[Epub ahead of print]
29. Barr RG, Mesia Vela S, Austin JHM, Keller
B, Reeves AP, Shimbo D, Stevenson L. Impaired flow-mediated dilatation of the
brachial artery is associated with low pulmonary function & emphysema in
ex-smokers. The EMCAP Study. Am J Respir Crit Care Med 2007;176:1200-7.
30. Sternberg D, Shimbo D, Kawut S, Sarkar J,
Herlitz G, D’Ovidio F, Lederer D, Wilt J, Arcasoy S, Pinsky D, D’Armiento J,
Sonett JR. Post-Operative Platelet Activation after Lung Transplantation. J
Thorac Cardiovasc Surg 2008;135:679-84.
31. Rieckmann N, Davidson KW, Clemow L,
Shimbo D, Pickering TG. Behavioral Medicine in the Treatment of Heart Disease. Hurst's
the Heart, Twelfth Edition. 2008
32. Frontera JA, Parra A, Shimbo D, Fernandez
A, Schmidt JM, Peter P, Claassen J, Wartenberg KE, Rincon F, Badjatia N,
Naidech A, Connolly ES, Mayer SA. Cardiac
arrhythmias after subarachnoid hemorrhage: risk factors and impact on outcome. Cerebrovasc Dis. 2008;26(1):71-8. Epub 2008 Jun 5.
33. Gerin, W, Goyal T, Shimbo D. The
Measurement of Blood Pressure in Cardiovascular Research. Handbook of
Physiological Research Methods in Health Psychology. 2008
Currently Funded Projects (Selected)
ACTIVE
K23 HL072866 (Shimbo)
NIH/NHLBI
Translational Studies of Hostility, Atherothrombosis & CAD
The major goal of this career development award is to enable me to develop into an independent, translational researcher with expertise in preventive cardiology. The goals of the proposed research program are to examine the relationship between hostility and its management on levels of inflammatory markers and platelet reactivity.
Role: Principal Investigator
(Shimbo)
IRVING SCHOLARS PROGRAM
A TRANSLATIONAL STUDY OF ANGER, ENDOTHELIAL CELL INJURY, AND OXIDATIVE STRESS
The major goal of this study is to examine the effect of anger induction on endothelial cell injury and to determine whether these dysregulations are partially explained by elevated levels of oxidative stress.
Role: Principal Investigator
R01 HL80665 (Davidson/Shimbo)
NIH/NHLBI
CAD INCIDENCE: DEPRESSION & INFLAMMATION RISK
The major goal of this study is to determine whether depression and inflammatory status independently predict incident CAD events in a population-based study.
Role: Co-Principal Investigator
CTSA/CTO (Shimbo/Whang)
PILOT STUDIES OF VENTRICULAR REMODELING, MICROVOLT T-WAVE ALTERNANS, AND SUDDEN CARDIAC DEATH
The major goals of these studies are to collect pilot data into (1) the relations among depression, left ventricular remodeling, and microvolt T-wave alternans after an acute coronary syndrome event, and (2) the relations among cardiac resynchronization therapy, ventricular remodeling, and microvolt T-wave alternans in heart failure patients.
Role: Principal Investigator (PI with Dr. Whang)
(Pickering)
CVRx, Inc.
RHEOS PIVOTAL TRIAL
The goal is to determine whether chronic baroreceptor activation using the Rheos Implantable Pulse Generator will be a safe and effective treatment for patients with refractory hypertension.
Role: Principal Investigator (site)
R01 HL082895 (Kawut)
NIH/NHLBI
A CLINICAL TRIAL OF ASPIRIN AND SIMVASTATIN IN PULMONARY ARTERIAL HYPERTENSION
This is a 2X2 factorial clinical trial of aspirin and simvastatin in pulmonary arterial hypertension. The goal is to study the combination of these drugs on platelet reactivity, endothelial function, endothelial biomarkers, and six-minute walk in patients with pulmonary arterial hypertension.
Role: Co-Investigator
R01 HL071264 (Badimon)
NIH/NHLBI
Translational Studies of Depression, Platelets, & CAD
The major goals of this project are to assess whether serotonin-mediated platelet reactivity and blood thrombogenicity are increased in depressed patients with CAD; and to determine the effects of cognitive behavioral therapy and antidepressants from two different classes (serotonin reuptake inhibitors and serotonin-2A-receptor antagonists) on these biological mediators.
Role: Co-Investigator
HC 25197 (Davidson)
NIH/NHLBI
CONSORTIUM FOR THE TRANSLATION OF PSYCHOSOCIAL DEPRESSION THEORIES TO INTERVENTION AND DISSEMINATION
The major goals of this contract are to understand the etiology, course, and treatment of the dysphoria following an acute coronary syndrome.
Role: Co-Investigator and Leader of Project 3
R24 HL76857 (Pickering)
NIH/NHLBI
MIND-BODY-BEHAVIORAL MED CLINICAL TRIALS INFRASTRUCTURE
The major goal of this project is to address five barriers that have impeded the impact of mind-body (behavioral) medicine in the general medical community. The barriers are addressed by four Cores (Core A-Administration, Core B-Mechanisms, Core C-Minority Health Oversight, Core D- Dissemination).
Role: Co-Investigator
NARSAD (Davidson)
A Randomized Controlled Trial of Inflammatory Markers, Depression, and Heart Disease
The major goal of this study is to pilot test a randomized placebo-controlled trial examining the effect of the antidepressant sertraline on depressive symptoms and CRP levels.
Role: Co-Investigator
(Shimbo)
Victoria and Ester Aboodi Award
ECHOCARDIOGRAPHIC VV OPTIMIZATION OF SEQUENTIAL BIVENTRICULAR PACING IN PATIENTS WITH ADVANCED HEART FAILURE
The major goal of this study is to determine the utility of 3D echocardiography in optimizing the VV delay in heart failure patients who have received a sequential biventricular pacer.
Role: Principal Investigator
COMPLETED
RR00645
NIH/Columbia GCRC Shimbo D (PI)
INFLAMMATORY MARKERS, ENDOTHELIAL FUNCTION, AND ANGER
The major goal of this pilot study was to determine the effects of an anger-recall task on inflammatory markers, and endothelial function.
Role: Principal Investigator
Pickering T, Davidson K, Badimon JJ (PIs)
Dana Foundation
Depression, Brain-mediated Circadian Rhythm Disruptions, and Heart Disease Risk
The major goals of this project were to assess the associations between major depressive disorder and an altered circadian rhythm; and the contribution of major depressive disorder to abnormal blood pressure control, heart rate variability, and platelet reactivity.
Role: Co-Investigator
Badimon JJ (PI)
Daiichi Pharmaceutical Inc.
Antithrombotic effects in humans of escalating doses of DX-9065a, a direct factor Xa inhibitor. Comparative study with low molecular weight heparin (enoxaparin).
The major goals of this project were to assess the effects of the novel direct factor Xa inhibitor, DX-9065a on thrombogenesis in healthy human volunteers.
Role: Co-Investigator
Awards
Alpha Omega Alpha Medical Society
Albany Medical College Alumni Scholarship
The Richard A. Barnett Internal Medicine Award
Best Teaching Fellow Award
Department of Medicine (Mount Sinai School of Medicine) Outstanding Research Award
Fellow of the Summer Institute on the Design and Conduct of Randomized Clinical Trials Involving, Behavioral and Social Interventions, Office of Behavioral and Social Sciences Research, NIH
Daniel V. Kimberg Memorial Junior Faculty Teaching Award, Dept of Medicine, Columbia University Medical Center
Medical Housestaff Teaching Award, Department of Medicine, Columbia University Medical Center
Ewig Clinical Scholar, Department of Medicine, Columbia University Medical Center
Victoria and Ester Aboodi Assistant Professor of Medicine
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