Information for Patients: Treatment of Hypertension

Can Hypertension Be Treated?

The good news is that high blood pressure is eminently treatable. The objective of treatment is not simply to lower the blood pressure, but to prevent its consequences, such as strokes and heart attacks. The benefits of treatment were first convincingly demonstrated in a landmark Veterans Administration study conducted by Dr Edward Fries, the first results of which were published in 1967. This study included 143 men with severe hypertension who had diastolic pressures between 115 and 129 mm Hg. Half of the men were treated with medication to lower the blood pressure, while the others received inert placebo pills. After only one and a half years, the results were quite clear: in the untreated group, four men had died, and 23 had developed complications such as strokes and heart attacks, while in the treated group none had died, and only two developed complications. This type of study is called a randomized clinical trial. Since this study was published, numerous larger trials involving tens of thousands of patients have been conducted, which have demonstrated conclusively that drug treatment can cut the number of strokes by about half and the number of heart attacks by a somewhat smaller amount. These studies have included younger people in whom both systolic and diastolic are elevated and older people in whom only systolic pressure is high. Both groups have shown similar benefit.

Non-Drug Treatment of Hypertension

People often think that the treatment of hypertension invariably involves having to take medications for the rest of one's life, but this is not necessarily the case. There is much that can be done with diet and exercise to lower the blood pressure. The traditional recommendation about diet was to restrict the intake of salt (to about 6 grams a day, or just over half the average American's typical intake), and while this method is still effective, it does not work in everyone. Some people (about one third of the hypertensive population) are "salt sensitive," which means that their blood pressure will respond to changing salt intake, while the rest are "salt resistant," in whom cutting out salt will have little effect on the blood pressure. Unfortunately, there is no simple test to decide who is salt sensitive and who is not.

A major advance in the treatment of hypertension has been the DASH (Dietary Approaches to Stop Hypertension) diet, which has been shown to lower blood pressure as much as medications.

For people who are overweight, the most effective method for lowering blood pressure is to lose weight.

The DASH Diet

The DASH (Dietary Approaches to Stop Hypertension) diet was designed to provide a palatable diet that would be good for general health and lower the blood pressure. It contains a lot of potassium, magnesium, and calcium, minerals that have been shown to lower blood pressure. The potassium and magnesium are provided by fruits and vegetables, and the calcium by low-fat dairy products. The diet was first tested in a very tightly controlled study sponsored by the National Institutes of Health in which participants were fed one of three diets for an 8-week period. The first was a "control" diet, equivalent to the average American diet; the second was a diet rich in fruits, grains, and vegetables, and the third was the "DASH" diet, which was similar to the fruit and vegetable diet but with the addition of low-fat dairy products. Salt intake was not reduced in any of the diets. The combination DASH diet produced the greatest reduction of blood pressure (11 mmHg systolic and 6 mmHg diastolic). The fruit and vegetable diet also lowered blood pressure (by 7 mmHg systolic and 3 mmHg diastolic). African-Americans showed a bigger response than whites.

A second DASH study examined the effects of varying the salt content of the diet. There were 412 patients with blood pressure in the "high normal" or mildly hypertensive range, who were randomly allocated to eat either a regular American diet or the DASH diet for 3 months. This was done by providing them with specially prepared meals. For each one of the 3 months the salt content was varied; the "high"-salt diet had 143 milliequivalents of sodium (3.3 grams), which is the same amount as the typical American diet; the "medium"-salt diet had 106 milliequivalents (3.3 grams), and the "low"-salt diet had 65 milliequivalents (1.5 grams).

While eating the regular US diet, the effect of salt restriction was to lower systolic pressure by 2.1 mmHg on going from the high to the medium salt intake, and by a further 4.6 mmHg on going from the medium to the low salt intake. Thus the effect of going from a high to a low salt intake was 6.7 mmHg. While on the DASH diet the same changes were seen, although not quite as much (4.0 instead of 6.7 mmHg). For people with mild hypertension, the reduction of blood pressure achieved by the combination of the DASH and low-salt diet was 11.5/5/7 mmHg, which is equivalent to the changes seen with blood pressure-lowering medications.

There is also an excellent book called The DASH Diet for Hypertension by Thomas Moore and colleagues, published by The Free Press at $25. It contains numerous sample meals.

Dr. Pickering has also written a book about hypertension for the general public: Good News About High Blood Pressure by Thomas Pickering MD, published by Simon and Shuster.

More information can be found at the NIH Web site about the DASH diet visit: http://www.nhlbi.nih.gov/health/public/heart/hbp/dash/

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To make an appointment, please call Jackie Herrera at 212-342-4489